Individuals with periodontitis exhibit elevated levels of IL-6 in their saliva and gingival crevicular fluid, reflecting its involvement in promoting immune responses and contributing to the resorption of periodontal tissue.21 RT induces inflammatory signaling and results in overexpression of interleukins, including IL-1β, IL-6, IL-8, TNF-α.22,23. The gene discussed is IL6; the disease is periodontitis.