Despite clustering generally with CIMP‐high cancers (Figures 2 and 3), IDH‐mutant CRCs had borderline significantly higher DNA methylation than other CIMP‐positive CRCs (TCGA‐COADREAD p = 0.049 and S:CORT p = 0.052, Wilcoxon test; supplementary material, Figure S7A,B). The gene discussed is IDH2; the disease is cancer.