IDH2 and colorectal carcinoma: Here, taking a hypothesis‐free approach and combining public TCGA‐COADREAD and 100kGP CRC data, we found IDH2 also to be a CRC driver for the first time using the IntOGen pipeline (https://intogen-plus.readthedocs.io/en/v2024/), principally based on four methods (dNdScv [21], OncodriveFML [22], MutPanning [25], and smRegions [27]) that identified the clustering of missense mutations predicted to be functionally important at codon 172 (z = 2.399, p = 0.008; Table 1).