There are no differences in the IBS subtypes; however, in IBS‐C, malondialdehyde correlated with IL‐4, and TNF‐α with IL‐10, suggesting an interleukin‐mediated anti low‐grade inflammation mechanism, and in IBS‐D, GSH correlated with IL‐4, suggesting an antioxidant mechanism. Here, IL10 is linked to irritable bowel syndrome.