Specifically, the MTL ROI effectively distinguished initial cognitive trajectories (A+/T− vs. A+/Tmod+), whereas the neo‐temporal and temporoparietal ROIs differentiated intermediate‐to‐advanced cognitive trajectories (A+/Tmod+ vs. A+/Tadv+), reflecting the expected relationship between ROI‐specific tau deposition and cognitive decline progression.3, 24, 47. The gene discussed is MAPT; the disease is Mental deterioration.