We observed that: (1) p‐tau181, p‐tau217, NfL, and GFAP levels increased along with increasing numbers of chronic diseases; and (2) p‐tau181, p‐tau217, t‐tau, NfL, and GFAP levels were significantly higher in individuals in the anemia/sensory impairment and cardiometabolic/inflammatory multimorbidity patterns compared to those in the unspecific one. The gene discussed is NEFL; the disease is anemia (phenotype).