Previous studies suggest that IGK enhances Nrf2/ARE signaling, which protects against obesity-induced cardiomyopathy (Wu et al. 2022), attenuates neurotransmitter deficiency and depression-like behaviors through downregulating p38/NF-κB signaling pathway (Li et al. 2021). The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.