To elucidate the reason for the exclusiveness between EBV GCs and MSI GCs, Kim et al. [7] knocked down MLH1 in SNU719 and NCC24 cells and reported that MLH1 knockdown did not affect cell proliferation, migration, or invasion but reduced tumor stemness, as evidenced by a decrease in CD44 expression status, tumor sphere formation, and xenograft tumor growth. Here, CD44 is linked to neoplasm.