NDUFB3 and Alzheimer disease: It has been suggested that Rpl35 may contribute to the development of AD by disrupting cellular processes and producing toxic aggregates after initiating protein misfolding.70 Our proteomic data showed deregulation in several NADH dehydrogenase (ubiquinone) subunits such as Ndufa3 and Ndufb3, which were correlated with several NDs including AD and HD.