Other proteins were involved in inflammation as in Stage 3 (C1qa), which is in line with our previous study with a TBI rat model.14 Complement is known to drive synaptic degeneration and progressive cognitive decline in the Chronic Stage after Traumatic Brain Injury.44 Consistent with this, Stage 6 in the ipsilateral cortex, represented by a large group of proteins, showed a restoration of several neuroprotective biological pathways in the subacute injury Stage (1 week). This evidence concerns the gene C1QA and Mental deterioration.