APOA1 and Alzheimer disease: Moreover, Apoa1 is the most thoroughly studied marker in PD among the apolipoproteins, where low levels of Apoa1 have been associated with the vulnerability of the dopaminergic system in symptomatic patients, suggesting its contribution to the early onset of PD.70,71 Recently, the pathogenic role of the ribosomal-related protein Rpl35 has been investigated in the AD mouse model.