Specifically, a decrease in Gria3 expression was reported in AD, whereas Gria4 was pathologically associated with PDD and DLB.72 Interestingly, Gria4, which has been identified as a synaptic marker of cognitive decline in neurodegenerative diseases, is downregulated in the ipsilateral cortical region in the acute injury Stage after single TBI, which may suggest a predictive molecular fingerprint of Gria4 and other synaptic proteins in our proteome associated with neurodegeneration after TBI. This evidence concerns the gene GRIA4 and Alzheimer disease.