2008). VAT is also a key producer of adipokines and modulates the inflammatory environment through macrophage‐derived pro‐inflammatory cytokines, such as IL‐6 and TNF‐α, which are elevated in obesity and contribute to chronic low‐grade inflammation (Balistreri et al. 2010). Mesenteric AT, located around the intestines, is particularly relevant as it plays a crucial role in local and systemic inflammation, it directly impact metabolic diseases such as insulin resistance, and is tightly connected to the intestinal barrier and microbiota (Kredel and Siegmund 2014). Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.