Neither the USP8 P681Q mutation identified in our patient nor the hotspot S718P variants affected murine corticotroph tumor cell proliferation (USP8-P681Q vs. USP8-S718P fold change: 1.12 ± 0.03 vs. 1.14 ± 0.07, ns, Fig. 3C). The gene discussed is USP8; the disease is neoplasm.