The contra-lateral (left) corticotroph tumor from our patient harbored a novel USP8 c.1724 C > A variant which causes a missense P681Q with 18.7% VAF (of 187 reads), which was further validated by amplicon NGS sequencing (23.8% VAF, 146 out of 614 reads). The gene discussed is USP8; the disease is neoplasm.