In 2023, Xu et al. utilize a Tri-gas incubator with 5% O2 and find that hypoxia increases autophagy, Fork-head box protein O1 (FOXO1), and Histone deacetylase 6 (HDAC6), but suppresses osteogenesis in rat bone marrow-derived mesenchymal stem cells (BMMSCs), which is verified by the unilateral nasal obstruction (UNO) rat model (Xu et al. 2023). The gene discussed is FOXO1; the disease is Nasal congestion.