It may result from the increase of fibroblast growth factor 23 (FGF23) the decrease of sclerostin (SOST) in the supernatant, as the secretion of FGF23 (a homeostatic regulator within mineralization and phosphate) facilitates the development and formation of osteoblasts (Xu et al. 2022a) and the decrease of SOST (a bone morphogenetic protein (BMP) antagonist) due to cyclic CF-indued autophagy may enhance osteoblast differentiation (Chen et al. 2020b). Here, FGF23 is linked to cystic fibrosis.