Osteocyte autophagy is activated under CF in a murine OTM model, and CF and Rapa not only induce autophagy but also increase the secretion of Receptor activator of nuclear factor-kappa B ligand (RANKL) in osteocyte-like cell line MLO-Y4 cells by 3-fold and 4-fold, respectively (Li et al. 2020). This evidence concerns the gene TNFSF11 and cystic fibrosis.