IRF3 and Friedreich ataxia: Since increasing evidence suggests the constitutive activation of the cGAS/STING/TBK1/IRF3 innate immune pathway in DNA-repair deficient cells and chromosome instability syndromes [35], including FA [36], we hypothesized that amlexanox may reduce p53 levels by mitigating the overactivation of TBK1/IKKε complex.