Univariate survival analysis revealed that HMOX1 expression (p < 0.0001), clinical stage (p = 0.003), pathological grade (p = 0.047), lymph node metastasis (p < 0.0001), and distant metastasis status (p = 0.004) were prognostic indicators of overall survival. Here, HMOX1 is linked to metastatic malignant neoplasm in the lymph nodes.