TP53 and neoplasm: Following tumor cellexposure to CBL0137, the FACT (FAcilitates Chromatic Transcription) chromatinremodeling complex becomes tightly associated with chromatin causing depletion offunctional FACT, leading to activation of the p53 tumor suppressor (viaphosphorylation by FACT-associated CK2) and inhibition of pathways dependent uponFACT [17] including NF-κB and heatshock factor 1 (HSF1) [18].