Elevated circulating levels of CTRP-1 have been reported in individuals with type II diabetes mellitus, obesity, atherosclerosis, hypertension, where it is thought to modulate immune and metabolic responses through cytokine regulation and other signaling pathways [13, 14, 28, 29]. This evidence concerns the gene C1QTNF1 and obesity due to melanocortin 4 receptor deficiency.