Blocking with excess EV-F(ab’)2 significantly reduced subsequent tumor uptake (6.27 ± 0.49%ID/g in NCI-N87, P = 0.0029; 5.23 ± 0.31%ID/g in H1975, P = 0.00074), confirming Nectin-4 specificity. This evidence concerns the gene NECTIN4 and neoplasm.