Several studies on breast cancer [58, 59], and epidermoid carcinoma [60] proved that decorin by binding to EGFR blocks PI3K and Ras signaling responsible for sustained tumor growth and activates anti‐angiogenic MAPK pathway in order to enhance the expression of cyclin inhibitor p21waf and thrombospondin‐1 (TSP‐1) [51]. This evidence concerns the gene EGFR and neoplasm.