Results: In patients with epilepsy associated with anti‐GAD 65 antibodies, a higher median of TNF‐alpha was observed compared to the rest of the sample (any anti‐GAD 65‐negative epilepsy), as well as compared to epilepsy cases without immunoreactivity (in which no antibodies were found in serum using advanced techniques such as indirect immunofluorescence on murine tissue). The gene discussed is TNF; the disease is epilepsy.