Homeobox A2 (HOXA2) was recently found to be overexpressed and an independent prognostic marker in high grade gliomas.1–3 Interestingly, some HPs have the astonishing property to travel between cell.4 More strikingly, these travelling HPs are able to enter target cell nucleus and thereby modify transcriptional activity, potentially spreading oncogenic dysregulation in the healthy neighboring cells.5–7 In this work, we investigated if HOXA2 is a travelling HP. Here, HOXA2 is linked to central nervous system cancer.