Methods: IgG purified from the peripheral blood of patients with anti‐NMDAR (n = 3) encephalitis, anti‐LGI1 encephalitis (n = 4) and healthy controls (HC) (n = 4) was administered chronically every other day for 11 days via stereotaxic injection into the lateral ventricle of genetic absence epilepsy rat model (GAERS) and Wistar rats. This evidence concerns the gene LGI1 and encephalitis.