Other types include kyphoscoliotic EDS (kEDS), which causes severe muscle weakness due to PLOD1 mutations, arthrochalasia EDS (aEDS) with extreme joint laxity resulting from COL1A1 or COL1A2 mutations, and dermatosparaxis EDS (dEDS) with fragile skin due to ADAMTS2 mutations [10–12]. Here, PLOD1 is linked to Ehlers-Danlos syndrome, arthrochalasia type.