NTN1 and idiopathic pulmonary fibrosis: Among the top 10 identified therapeutic pathways, UNAGI identifies pathways whose role in IPF is relatively less studied such as the Netrin-1 signalling pathway (score = 0.6548, false discovery rate (FDR) = 3.4698 × 10−19), which is indicated to be mechanistically important in pulmonary fibrosis87,106; signalling by ROBO receptors (score = 0.5890, FDR = 1.1028 × 10−14)64,107; and GPCR signalling pathways, which are associated with G proteins, known to promote fibrosis, and have also generated interest as targets for IPF interventions108.