NOD2 and Crohn disease: The mutant allele carrier status of the three main Crohn’s disease-associated NOD2 mutations, p.Arg702Trp [univariable: β (95% CI) =  − 0.130 (− 0.382, 0.123), p = 0.31], p.Gly908Arg [univariable: β (95% CI) =  − 0.157 (− 0.536, 0.222), p = 0.42], and p.Leu1007fsX1008 [univariable: β (95% CI) =  − 0.030 (− 0.251, 0.191), p = 0.79], did not have any significant impact on systemic CCL20 levels in patients with Crohn’s disease (Table 3).