All tumor types had significantly higher SMO expression than non-inflamed stroma (Kruskal-Wallis test, P < 0.001, with post hoc pairwise comparisons using Dunn’s test P < 0.001 for stroma vs. BCC, P < 0.001 for stroma vs. SCC, and P < 0.001 for stroma vs. SEB). Here, SMO is linked to neoplasm.