ENO2 and bone metastasis: Regarding OS in the general study population, multivariate analyses with stepwise regression identified CRP > ULN, LDH > 2x ULN, NSE > 3x ULN, progression of bone metastasis only, PSAR and TT median < DL as independent predictors (Table3) For the subgroups, the following independent prognostic factors remained for OS: LDH > 2x ULN, FT nadir < 0.2 pg/mL and FT median < DL (group 1); requirement for non-narcotics and PSAR (group 2); LDH > 2x ULN and pulmonary metastasis (group 3).