Finding the above mentioned significant effect of HCQ and FIN on BPH-induced rats, it was noteworthy to gain insight into the ability of these drugs to modulate, not only the expression, but also the activity of STAT3/FOXO1/TRAIL and EGFR/ERK/AR pathways’ members through a molecular docking study. Here, TNFSF10 is linked to benign prostatic hyperplasia.