According to the experimental scheme detailed in Fig. 8A, ISCU-deficient macrophages significantly enhanced OVA-specific CD8+ T cell proliferation (Fig. 8B) and stimulated these T cells to secrete anti-tumor cytokines, including TNF-α, IFN-γ, and Granzyme B (Fig. 8C–E). Here, GZMB is linked to neoplasm.