The enhanced anti-tumor effect of ISCU-deficient macrophages appeared to be dependent on increased CD8+ T cell infiltration (Fig. 8J) and their augmented anti-tumor activity (e.g. TNF-α, IFN-γ and Granzyme B secretions) within the tumor microenvironment (Fig. 8K–M). The gene discussed is TNF; the disease is neoplasm.