LRRK2 and Parkinson disease: This data shows that PD mutations affect alpha-synuclein pathology in a cell and mutation type specific manner, with PRKN lof increasing alpha-synuclein puncta only in dopamine neurons, whereas LRRK2 R1441G mutation had decreased numbers of alpha-synuclein puncta that were more phosphorylated at S129 only in cortical neurons.