BSG and gastric cancer: Receiver operating characteristic analysis demonstrated that the expression levels of CD147 mRNA in gastric tissue (healthy = 32, GC = 375) from the TCGA database indicated moderate diagnostic accuracy for GC (AUC = 0.789) (Fig. 6J), while CD147 protein levels in plasma EVs (healthy = 34, GC = 67) exhibited higher diagnostic accuracy (AUC = 0.984, Fig. 6K).