The results suggested that MK2206 reversed the CD147-high gcEVs induced promotion of endothelial cell permeability, tumor cell transendothelial migration, cytoskeletal rearrangement, and internalization of VE-cadherin, whereas SC79 reverted the inhibitory effect of CD147-knockdown gcEVs (Figs. S8 and S9). This evidence concerns the gene CDH5 and neoplasm.