In AD and other tauopathies, intraneuronal accumulation of hyperphosphorylated tau leads to the formation of neurofibrillary tangles (NFTs) (Garcini et al., 1986; Grundke-Iqbal et al., 1986; Kidd, 1963; Seubert et al., 1995). Here, MAPT is linked to Alzheimer disease.