C9 and amyotrophic lateral sclerosis: Analysis of “motor neuron death” (net Td-Tomato change between the first and last time points) showed that MNs co-cultured with C9-ALS microglia exhibited significantly higher death counts compared to those co-cultured with CTRL microglia, and telmisartan treatment reduced MN death in the C9-ALS co-culture to levels similar to CTRL microglia (Figure 4G).