IL-6 and IL-8 have emerged as neuroinflammatory signatures in the context of ALS, with some studies highlighting their elevated levels in human ALS cerebrospinal fluid (CSF) and plasma (Mennini et al., 2009; Moreau et al., 2005; Wosiski-Kuhn et al., 2021). Here, CXCL8 is linked to amyotrophic lateral sclerosis.