H2BC21 and amyotrophic lateral sclerosis: To assess telmisartan’s effect on spinal MN survival under C9-ALS conditions, we generated spinal MNs from a GPI:H2B-tdTomato-tagged hESC line (Guttikonda et al., 2021) and cultured them alone or with C9-ALS or CTRL glia (microglia and/or spinal astrocytes) under mono-, co-, and triculture conditions.