Given the heterogeneity imposed by genetic background, we used 1 female and 1 male isogenic pair of human iPSCs in addition to 1 control APOE3/3 (3/3) and 1 patient with AD APOE4/4 (4/4) female lines, totaling 6 iPSC lines with three lines per genotype (Table 1). Here, APOE is linked to Alzheimer disease.