Epithelioid sarcomas (CD34- and ERG-positive) lack Cluster of Differentiation (CD31) and Integrase Interactor 1/SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (INI/SMARCB1), unlike angiosarcomas, while melanomas are S100, SRY-related HMG-box 10 (SOX10), and melan-A positive but negative for vascular markers necessitating immunohistochemical panels for accurate diagnosis [5]. The gene discussed is SMARCB1; the disease is melanoma.