While there is convergence across murine and human-derived models of PD indicating an upregulation of macroautophagy and mitophagy, it is worth noting that these data is congruent with several studies conducted in postmortem brain tissue showing increased levels of LC3-II which likely reflects impaired macroautophagy in idiopathic cases of PD, but not in familial case of a PD human harboring the LRRK2-G2019S mutation [65]. The gene discussed is LRRK2; the disease is Parkinson disease.