SNCA and Parkinson disease: In iPSC-derived DA neurons, several studies performed in PD-patient derived fibroblasts harboring mutations in oligomerization-prone mutant α-synuclein (E57K) that were converted TH-positive neurons, or that express a mutant of Miro1 (R272Q) showed significantly impaired baseline or reduced anterograde mitochondrial trafficking along with decreased expression of Miro1 [152, 153].