SNCA and Parkinson disease: Showing convergence across in vitro and in vivo models of PD, this mitochondrial pathology induced by mutant α-synuclein is further exemplified in iPSC-derived DA neurons that express three copies of the SNCA gene or mutant A53T SCNA as evidenced by overt mitochondrial fragmentation, decreased baseline and maximal mitochondrial respiration and decreased transmembrane potential [192].