Consistent with this view, cell culture models that overexpress LRRK2-G2019S exhibit overactivated macroautophagy and loss of neurites in SH-SY5Y cells leading to a reduction in mitochondrial levels [47, 53], whereas LRRK2 G2019S knock-in-mice show impaired basal mitophagy that contributes to PD pathology [54]. The gene discussed is LRRK2; the disease is Parkinson disease.