TFAM and Parkinson disease: However, it is also worth emphasizing that in addition to a decrease in the protein levels of TFAM, PGC-1α as well as the level of several proteins in mitochondria have been shown to be reduced in the SN and striatum of postmortem PD tissue which is consistent murine and human-derived models of PD, and thereby underscores the importance of analyzing mitochondrial biogenesis-related signaling pathways in multiple complementary PD models [90].