In conclusion, this large-scale study used integrated computational analysis to uncover critical hub genes (S100A12, CXCL8, IL1RN, S100A9, CXCL10, MMP1, CXCL1, FPR1, CXCR2, S100A8) linked to Crohn’s disease (CD) and psoriasis. Here, CXCL10 is linked to Crohn disease.