IL1RN and Crohn disease: In conclusion, this large-scale study used integrated computational analysis to uncover critical hub genes (S100A12, CXCL8, IL1RN, S100A9, CXCL10, MMP1, CXCL1, FPR1, CXCR2, S100A8) linked to Crohn’s disease (CD) and psoriasis.