CXCR2 and colitis: In the colitis mouse model of induced by sodium dextran sulfate (DSS), CXCR2 is highly expressed in inflammatory intestinal tissue [51].In addition to inducing neutrophil activation, CXCR2 can also mediate the activation and proliferation of keratinocytes, which together lead to characteristic changes in the epidermis of psoriatic skin lesions [52].