In conclusion, this large-scale study used integrated computational analysis to uncover critical hub genes (S100A12, CXCL8, IL1RN, S100A9, CXCL10, MMP1, CXCL1, FPR1, CXCR2, S100A8) linked to Crohn’s disease (CD) and psoriasis. Here, S100A12 is linked to psoriasis.