In conclusion, this large-scale study used integrated computational analysis to uncover critical hub genes (S100A12, CXCL8, IL1RN, S100A9, CXCL10, MMP1, CXCL1, FPR1, CXCR2, S100A8) linked to Crohn’s disease (CD) and psoriasis. The gene discussed is CXCL8; the disease is psoriasis.