ANGPTL2 and systemic sclerosis: Bioinformatic analysis of Angptl2 gene expression in published datasets of keloid (35) and SSc (36) patients and fibrotic diseases of other human organs, such as the lung (37), kidney (38), and liver (39), revealed that Angptl2 is upregulated in diseased skin compared with healthy skin controls (Figure 3D and Supplemental Figure 4, B–D).