We also identified common missense SNVs in TTN (rs3829746-C) and BAG3 (rs2234962-C) that have been previously associated with a lower risk of sporadic DCM in the general population.7,32 These SNVs were also associated with a 19% reduced risk of late-onset CCM in childhood cancer survivors, with similar magnitudes of association. The gene discussed is BAG3; the disease is cerebral cavernous malformation.