BAG3 and cerebral cavernous malformation: Additionally, another study identified a common missense variant, rs2234962-C, in BAG3 that was associated with decreased sporadic DCM risk, while rare variants in the same gene were associated with increased familial DCM risk.10,11 The association of rs2234962-C with DCM has been replicated in several association studies,7,8,12,13,14 with additional support from a functional study.15 However, the potential role of genetic variants in TTN and BAG3 in the risk of late-onset (occurring ≥5 years after childhood cancer diagnosis) CCM among childhood cancer survivors remains unknown.