In SJLIFE European ancestry participants, minor alleles of both common missense SNVs in TTN (rs3829746-C: odds ratio [OR], 0.73; 95% CI, 0.55-0.97; P = .03) and BAG3 (rs2234962-C: OR, 0.73; 95% CI, 0.55-0.96; P = .03) were significantly associated with a reduced risk of late-onset CCM (Table 2). Here, BAG3 is linked to cerebral cavernous malformation.