Here, we investigated the possible involvement of TRPV1 channels and μ-opioid receptors in mediating the antinociception of the KATP opener, nicorandil, in neuropathic pain in four nociceptive models: chronic constriction injury of the sciatic nerve (CCI), formalin, capsaicin, and acetic acid writhing tests. Here, TRPV1 is linked to neuropathic pain.