The second cluster group comprises tumours caused by mutations in the neurofibromatosis type 1 (NF1) tumour suppressor gene, the rearranged during transfection (RET) proto-oncogene, the transmembrane protein 127 (TMEM127) gene and the MYC-associated factor X (MAX) gene [166–169]. The gene discussed is TMEM127; the disease is neoplasm.