Hypertension onset has been described at 1–3 months of life associated with the Gly403Asp and Thr776Ala variants, and at age 5 associated with the Ile770Met variant [104, 107].Recently, a case of de novo mosaicism of the Phe767Leu variant was described in a patient with Chiari malformation, chorea, developmental delay, neonatal hypoglycaemia, and low renin levels [102]. The gene discussed is REN; the disease is hypertensive disorder.