Next-generation sequencing analyses have identified somatic mutations of KCNJ5 in about 40% of aldosterone-producing adrenocortical adenomas, associated with more severe hyperaldosteronism, suggesting a direct role of KCNJ5 in determining aldosterone overproduction and proliferation of the zona glomerulosa cells [58, 80]. This evidence concerns the gene KCNJ5 and adrenal cortex adenoma.