306 human ESCC tissue specimens were analyzed by immunohistochemistry (IHC) for membranous expression density and frequency of β6-integrin (ITGB6), which only dimerizes with αv-integrin and thus is limiting and indicative for actual membranous αvβ6-integrin abundance [13]. The gene discussed is ITGB6; the disease is esophageal squamous cell carcinoma.