CD274 and neoplasm: Current biomarkers (such as programmed death ligand 1 [PD‐L1] expression, tumor mutation burden [TMB], microsatellite instability [MSI]) rely on invasive tissue sampling and are confounded by spatiotemporal tumor heterogeneity.[20, 21] A preoperative imaging‐based subtyping system that integrates prognostic prediction with biological insights could optimize holistic ccRCC management.