Notably, autophagy acts as a double‐edged sword, both playing a role in and being influenced by cardiac aging.[41, 42, 43] Previous studies have shown that PPT1 regulates autophagy in the context of tumor immunity and skeletal muscle differentiation.[44, 45] These results suggest that IPA regulates macrophage autophagy via PPT1 in aging model. Here, PPT1 is linked to neoplasm.