STING activation in cardiomyocytes triggers downstream signaling cascades, leading to increased production of pro‐inflammatory cytokines and transforming growth factor‐beta (TGF‐β), which ultimately contribute to myocardial fibrosis.[23] In this study, we investigated the specific mechanism by which IPA inhibits PPT1 activation and induces autophagy. The gene discussed is PPT1; the disease is Myocardial fibrosis.