Pharmaceutical correctors bind and stabilize CFTR forproper maturation and function at the cell surface., Amongavailable correctors, the second-generation corrector VX-445 (Elexacaftor)can treat a wide range of CF-causing variants including the most commonF508del variant.−,  Several side effects from these correctors, suchas hepatotoxicity, abdominal pain, severe rashes, depression, etc.,and importantly, adverse drug interactions leading to liver damagehave been reported, emphasizing the need to understand the etiologyof these effects that potentially arise from off-targets.−, , ,. The gene discussed is CFTR; the disease is cystic fibrosis.