SLC25A22 and epilepsy: Previous studies have shown that SLC25A22 inactivation in astrocyte mitochondria decreased nicotinamide adenine dinucleotide (NAD+) and ATP levels, and resulted in accumulated intracellular glutamate, which may be responsible for the increased intracellular Ca2+, altered neuronal synchronicity and epilepsy in SLC25A22-deficient patients (Goubert et al., 2017; Green et al., 2021; Mark et al., 2001).