Several recent studies have indicated that small molecules, iron, modified viruses as viral vectors, chemotherapeutic agents, and nanomedicines[9] can induce GSDMD/GSDME‐mediated pyroptosis in various malignant cancers.[10] Nevertheless, most existing pyroptotic inducers lack specificity and potency for particular cell types, causing undesirable adverse effects.[11] Therefore, an urgent and unmet need remains for developing tumor‐selective pyroptosis inducers. Here, GSDMD is linked to neoplasm.