Although our study did not comprehensively analyze the impact of NIR‐pyroptosis on innate and adaptive immune cell populations within the tumor, we did, indeed, observe a substantial increase in IFN‐γ levels in the supernatant of mouse splenocytes from NIR‐pyroptosis cured mice rechallenged with CT26.WT‐hHER2 cells. Here, IFNG is linked to neoplasm.