CD4 and psoriasis: In various psoriasis models such as HaCaT cells, K14‐VEGF‐A transgenic mice, and imiquimod‐induced psoriasis mice, IL‐35 has been shown to inhibit the production of pro‐inflammatory cytokines such as IL‐6, CXCL8, and S100A7, while increasing IL‐10 and regulatory T cells (CD4 + IL‐10+ and CD4 + CD25+Foxp3 + ).