For instance, cognitive impairment in delirious conditions is more severe in the rest phase than in the activity phase, due to diurnal variations in microglial activation and ensuing neuroinflammation under the control of the clock component E4BP4.[20] In line with the essential role of the circadian system in controlling cognition, small‐molecule modifiers of clock components (e.g., SR8278 for REV‐ERB and nobiletin for ROR) confer a neuroprotective effect and ameliorate cognitive impairments.[20, 21]. This evidence concerns the gene CLOCK and Cognitive impairment.