In sharp contrast, NECA (5′‐N‐ethylcarboxamidoadenosine, an A2R agonist, 0.08 mg kg−1, i.p.), CGS21680 (a specific A2AR agonist, 0.1 mg kg−1, i.p.)and SCH58261 (a specific A2AR antagonist, 0.1 mg kg−1, i.p.)had no effects on Bmal1‐iKO‐induced cognitive decline (Figure 4K,L; Figure S7K–P, Supporting Information). This evidence concerns the gene ADORA2A and Mental deterioration.