Ttc4 and its other family members were found to play important roles in the cell cycle and transcriptional regulation and to be relevant to type 2 diabetes development.[24] Therefore, chromatin remodeling and gene accessibility were evidently affected after acute Brd4 knockout in β cells, which highlights the important roles that Brd4 plays in β cells. This evidence concerns the gene TTC4 and type 2 diabetes mellitus.