Furthermore, KPNA2 is implicated in the regulation of various inflammatory and cancer‐related factors by transporting transcription factors such as P53, STAT3, and E2F into the nucleus.[34] Therefore, it is of significant interest to explore whether tRF‐5004b facilitates the nuclear translocation of other key transcription factors via KPNA2 for essential biological functions. Here, TP53 is linked to cancer.