RAC1 and neoplasm: reported that Rac1 is a core member of the Rho family, which is the most important class of small GTPases that interact with IQGAP1, was activated by IQGAP1, thereby driving the EMT process and promoting tumor invasion and metastasis.[41] The present ssGSEA derived from TCGA supported this conclusion (Figure S4E, Supporting Information).