MLKL knockdown (Figure S2J, Supporting Information) did not reverse the decrease in podocyte marker protein nephrin and synaptopodin expression (Figure 4I,J; Figure S2K, N, Supporting Information) or prevent HG‐induced podocyte death (Figure 4K,L), indicating that necroptosis pathway was not involved in podocyte injury of DKD. The gene discussed is SYNPO; the disease is diabetic kidney disease.