MLKL knockdown (Figure S2J, Supporting Information) did not reverse the decrease in podocyte marker protein nephrin and synaptopodin expression (Figure 4I,J; Figure S2K, N, Supporting Information) or prevent HG‐induced podocyte death (Figure 4K,L), indicating that necroptosis pathway was not involved in podocyte injury of DKD. This evidence concerns the gene MLKL and diabetic kidney disease.